Emergence of Clinical Pseudomonas aeruginosa Isolate Guangzhou-PaeC79 Carrying crpP, blaGES-5, and blaKPC-2 in Guangzhou of China

作者：Wang, Lin-Jing; Chen, En-Zhong; Yang, Ling; Feng, Dong-Hua; Xu, Zhenbo^*; Chen, Ding-Qiang^*

来源：MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 2021, 27(7): 965-970.

DOI：10.1089/mdr.2020.0420

• P
• aeruginosa
• bla(GES-5)
• crpP
• bla(KPC-2)

As a potential "Superbug," Pseudomonas aeruginosa remains the leading concern in antimicrobial resistance. In this study, the emergence of clinical P. aeruginosa isolate was found to carry crpP and bla(GES-5) on the chromosome and bla(KPC-2) on a plasmid. A clinical P. aeruginosa strain Guangzhou-PaeC79 with an extensively drug-resistant phenotype was isolated, which was resistant to all classes of clinical commonly used antibiotics. It contains one chromosomal DNA and one plasmid, with seven acquired antimicrobial resistance genes identified on the chromosome, including carbapenem resistance gene bla(GES-5) and fluoroquinolone resistance gene crpP, and carbapenem resistance gene bla(KPC-2) located on an IncP-6-type plasmid pPAEC79 carrying a Tn3-like element. Carriage of any two of the resistance genes has never been previously reported, and simultaneous carriage of three bla and crpP may explain the bacterial phenotype as high-level resistance to imipenem and meropenem (>= 16 mu g/mL) and resistance to ciprofloxacin and levofloxacin.

• 单位
  广州医学院; 南方医科大学; 1