Climate and nutrients regulate biographical patterns and health risks of antibiotic resistance genes in mangrove environment br

Authors：Zhao, Huaxian; Zhang, Junya; Chen, Xing; Yang, Shu; Huang, Haifeng; Pan, Lianghao; Huang, Liangliang; Jiang, Gonglingxia; Tang, Jinli; Xu, Qiangsheng; Dong, Ke; Li, Nan^*

Source：Science of the Total Environment, 2023, 854: 158811.

DOI：10.1016/j.scitotenv.2022.158811

• Antibiotic resistance genes
• Mangrove ecosystem
• Human health risk
• Biogeographic pattern
• Mobile genetic elements

Mangroves are prone to receive pollutants and act as a sink for antibiotic resistance genes (ARGs). However, knowl-edge of the human health risk of ARGs and its influencing factors in mangrove ecosystems is limited, particularly atlarge scales. Here, we applied a high-throughput sequencing technique combined with an ARG risk assessment frame-work to investigate the profiles of ARGs and their public health risks from mangrove wetlands across South China. Wedetected 456 ARG subtypes, and found 71 of them were identified as high-risk ARGs, accounting for 0.25 % of the totalARG abundance. Both ARGs and bacterial communities showed a distance-decay biogeography, but ARGs had asteeper slope. Linear regression analysis between features of co-occurrence network and high-risk ARG abundance im-plies that greater connections in the network would result in higher health risk. Structural equation models showed that geographic distance and MGEs were the most influential factors that affected ARG patterns, ARGs and MGEs con-tributed the most to the health risk profiles in mangrove ecosystems. This work provides a novel understanding of bio-geographic patterns and health risk assessment of ARGs in mangrove ecosystems and can have profound significance for mangrove environment management with regard to ARG risk control

• Institution
  中国海洋大学; 中国科学院; 桂林理工大学