Aggregation-induced emission luminogens for image-guided surgery in non-human primates

作者：Zhong, Danni; Chen, Weiyu; Xia, Zhiming; Hu, Rong; Qi, Yuchen; Zhou, Bo; Li, Wanlin; He, Jian; Wang, Zhiming; Zhao, Zujin; Ding, Dan; Tian, Mei; Tang, Ben Zhong^*; Zhou, Min^*

来源：Nature Communications, 2021, 12(1): 6485.

DOI：10.1038/s41467-021-26417-2

• NEAR-INFRARED FLUORESCENCE
• FOLATE RECEPTOR
• INDOCYANINE GREEN
• OVARIAN-CANCER
• CARCINOMA
• THERAPY
• NANOPARTICLES
• AGENT
• DOTS

Most applications of aggregation-induced emission luminogens (AIEgens) have been limited in small animal models. Here, the authors show the versatility of AIEgens-based imaging-guided surgical operation from small animals to rhesus macaque, in support of the clinical translation of AIEgens. @@@ During the past two decades, aggregation-induced emission luminogens (AIEgens) have been intensively exploited for biological and biomedical applications. Although a series of investigations have been performed in non-primate animal models, there is few pilot studies in non-human primate animal models, strongly hindering the clinical translation of AIE luminogens (AIEgens). Herein, we present a systemic and multifaceted demonstration of an optical imaging-guided surgical operation via AIEgens from small animals (e.g., mice and rabbits) to rhesus macaque, the typical non-human primate animal model. Specifically, the folic conjugated-AIE luminogen (folic-AIEgen) generates strong and stable fluorescence for the detection and surgical excision of sentinel lymph nodes (SLNs). Moreover, with the superior tumor/normal tissue ratio and rapid tumor accumulation, folic-AIEgen successfully images and guides the precise resection of invisible cancerous metastases. Taken together, the presented strategies of folic-AIEgen based fluorescence intraoperative imaging and visualization-guided surgery show potential for clinical applications.

• 单位
  南开大学; 浙江大学