Estimated 24-h urinary sodium excretion and risk of end-stage kidney disease

作者：Shan, Ying; Bai, Yong; Zhang, Jingwen; Lu, Yueqi; Yu, Sike; Song, Congying; Liu, Juehan; Jian, Min; Xu, Junjie; Ding, Changhai; Xiong, Zuying^*; Huang, Xiaoyan^*

来源：iScience, 2023, 26(5): 106728.

DOI：10.1016/j.isci.2023.106728

• BLOOD-PRESSURE
• CARDIOVASCULAR-DISEASE
• POTASSIUM EXCRETION
• RENAL-FUNCTION
• RESTRICTION
• ASSOCIATION
• TRIAL
• SALT
• POPULATION
• INHIBITION

The association between sodium intake and long-term kidney disease endpoints is debated and yet to be proven. We aimed to investigate the associations of estimated 24-h urinary sodium excretion, reflecting daily sodium intake, with the incidence of end-stage kidney disease (ESKD). In this prospective cohort study including 444,375 UK Biobank participant, 865 (0.2%) ESKD events occurred after median follow-up of 12.7 years. For every 1 g increment in estimated 24-h urinary sodium excretion, multivariable-adjusted hazard ratio for incident ESKD was 1.09 (95% confidence interval 0.94-1.26). Nonlinear associations were not detected with restricted cubic splines. The null findings were confirmed by a series of sensitivity analyses, which attenuated potential bias from measurement errors of the exposure, regression dilution, reverse causality, and competing risks. In conclusion, there is insufficient evidence that estimated 24-h urinary sodium excretion is associated with the incidence of ESKD.

• 单位
  北京大学; 南方医科大学; 深圳华大基因研究院