Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance

Authors：Huang, Jiewu; Kong, Yaozhong; Xie, Chao; Zhou, Lili^*

Source：Stem Cell Research & Therapy, 2021, 12(1): 197.

DOI：10.1186/s13287-021-02266-0

• Stem
• progenitor cells
• Kidney
• Microenvironment
• Therapy

Renal failure has a high prevalence and is becoming a public health problem worldwide. However, the renal replacement therapies such as dialysis are not yet satisfactory for its multiple complications. While stem/progenitor cell-mediated tissue repair and regenerative medicine show there is light at the end of tunnel. Hence, a better understanding of the characteristics of stem/progenitor cells in kidney and their homing capacity would greatly promote the development of stem cell research and therapy in the kidney field and open a new route to explore new strategies of kidney protection. In this review, we generally summarize the main stem/progenitor cells derived from kidney in situ or originating from the circulation, especially bone marrow. We also elaborate on the kidney-specific microenvironment that allows stem/progenitor cell growth and chemotaxis, and comment on their interaction. Finally, we highlight potential strategies for improving the therapeutic effects of stem/progenitor cell-based therapy. Our review provides important clues to better understand and control the growth of stem cells in kidneys and develop new therapeutic strategies.

• Institution
  南方医科大学; 佛山市第一人民医院