Comparison of Vascular Response to Statin Therapy in Patients With Versus Without Diabetes Mellitus

作者：Kurihara, Osamu; Thondapu, Vikas; Kim, Hyung Oh; Russo, Michele; Sugiyama, Tomoyo; Yamamoto, Erika; Fracassi, Francesco; Minami, Yoshiyasu; Wang, Zhao; Lee, Hang; Yonetsu, Taishi^*; Jang, Ik-Kyung^*

来源：American Journal of Cardiology, 2019, 123(10): 1559-1564.

DOI：10.1016/j.amjcard.2019.02.020

• OPTICAL COHERENCE TOMOGRAPHY
• ACUTE CORONARY SYNDROME
• LIPID-LOWERING THERAPY
• FIBROUS-CAP THICKNESS
• INTRAVASCULAR ULTRASOUND
• RICH PLAQUE
• DISEASE
• ATORVASTATIN
• INFLAMMATION
• LESSONS

Diabetes mellitus (DM) increases cardiovascular morbidity and mortality. A statin is routinely prescribed to patients with DM. However, whether a statin therapy is equally effective in plaque stabilization in DM patients compared with non-DM patients is unknown. A total of 117 lipid-rich plaques were imaged in 90 patients (54 plaques in 41 DM patients and 63 plaques in 49 non-DM patients) with coronary artery disease, those who were treated with a statin and underwent serial optical coherence tomography imaging were included in this study (mean follow-up period, 362 +/- 38 days). The changes in minimum fibrous cap thickness (FCT) and lipid index between baseline and 1-year follow-up were compared between the 2 groups. Minimum FCT increased and lipid index decreased with statin therapy in both groups. No significant differences were observed in percent changes of minimum FCT (p = 0.796) and lipid index (p = 0336) between DM and non-DM patients. Statin therapy induced a significant increase in FCT and a significant decrease in lipid index in both groups. Vascular response to statin therapy was similar between the 2 groups irrespective of DM status.

• 单位
  电子科技大学