Photocatalytic C-H Disulfuration for the Preparation of Indolizine-3-disulfides

Authors：Wu, Songxin; Hu, Dangzhong; Wan, Xuegui; Zhao, Jiaji; He, Qiuxing; Su, Zhengquan; Cao, Hua^*

Source：Journal of Organic Chemistry, 2022, 87(24): 16297-16306.

DOI：10.1021/acs.joc.2c01871

• DISULFIDE
• ACID
• IDENTIFICATION
• INDOLIZINES
• REAGENT

A photocatalytic C-H disulfuration of indolizines was developed, giving an approach to a wide variety of indolizine-3-disulfides with good yields. Trisulfide dioxides were explored as a high-efficient disulfuration reagent. This disulfuration reaction could be scaled up to grams. Mechanistic studies support a photoinduced pathway involving the generation of indolizine cationic radicals. A bulky alkyl substituent on terminal sulfur of trisulfide dioxide A was necessary for selective formation of disulfide over monosulfide.

• Institution
  广东药学院