Multifunction in One Nanoparticle for Anticancer Therapy: Bowl-Shaped Au@PDA Yolk-Shell NPs

作者：Ding, Xin; Wang, Tianyu; Bai, Shiwei; Wan, Yunfeng; Zhu, Shuai; Li, Tao; Peng, Na^*; Qiu, Tao^*; Liu, Yi^*

来源：ACS applied materials & interfaces, 2022, 14(24): 27733-27742.

DOI：10.1021/acsami.2c07671

• bowl-shaped nanoparticles
• pH/NIR dual-responsive properties
• photothermal therapy
• chemotherapy
• CT/PA imaging

Multifunctional nanoparticles (NPs) with simultaneous multimodal therapeutic and imaging capabilities are very necessary for biomedical applications. We successfully prepared bowl-shaped gold@ polydopamine yolk-shell NPs (bowl-shaped Au@PDA YNPs) by a novel and facile method. The unique bowl-like structure enables a drug loading rate of 92% (920 mu g mg(-1)). The bowl-shaped Au@PDA YNPs are biocompatible, have good photothermal conversion and strong nearinfrared (NIR) absorption, and can control drug release under pH/NIR dual response. Bowl-shaped Au@PDA YNPs can also be employed as contrast agents for computed tomography/photoacoustic imaging for dual-modal imaging-guided chemotherapy and photothermal therapy due to the presence of Au NPs.

• 单位
  武汉大学; y