Neuronavigated repetitive transcranial magnetic stimulation improves depression, anxiety and motor symptoms in Parkinson's disease

作者：Jiang, Shuolin; Zhan, Cuijing; He, Peikun; Feng, Shujun; Gao, Yuyuan; Zhao, Jiehao; Wang, Limin; Zhang, Yuhu; Nie, Kun; Qiu, Yihui; Wang, Lijuan^*

来源：Heliyon, 2023, 9(8): e18364.

DOI：10.1016/j.heliyon.2023.e18364

• Parkinson's disease
• Depression
• Transcranial magnetic stimulation
• Dorsolateral prefrontal cortex
• Neuronavigation

Background: Repetitive transcranial magnetic stimulation (rTMS) is a potential treatment option for Parkinson's disease patients with depression (DPD), but conflicting results in previous studies have questioned its efficacy. @@@ Method: To investigate the safety and efficacy of neuronavigated high-frequency rTMS at the left DLPFC in DPD patients, we conducted a randomized, double-blind, sham-controlled study (NCT04707378). Sixty patients were randomly assigned to either a sham or active stimulation group and received rTMS for ten consecutive days. The primary outcome was HAMD, while secondary outcomes included HAMA, MMSE, MoCA and MDS-UPDRS-III. Assessments were performed at baseline, immediately after treatment, 2 weeks, and 4 weeks post-treatment. @@@ Results: The GEE analysis showed that the active stimulation group had significant improvements in depression, anxiety, and motor symptoms at various time points. Specifically, there were significant time-by-group interaction effects in depression immediately after treatment (beta, -4.34 [95% CI, -6.90 to -1.74; P = 0.001]), at 2 weeks post-treatment (beta, -3.66 [95% CI, -6.43 to-0.90; P = 0.010]), and at 4 weeks post-treatment (beta, -4.94 [95% CI, -7.60 to -2.29; P < 0.001]). Similarly, there were significant time-by-group interaction effects in anxiety at 4 weeks post-treatment (beta, -2.65 [95% CI, -4.96 to -0.34; P = 0.024]) and in motor symptoms immediately after treatment (beta, -5.72 [95% CI, -9.10 to -2.34; P = 0.001] and at 4 weeks post-treatment (beta, -5.43 [95% CI, -10.24 to -0.61; P = 0.027]). @@@ Conclusion: The study suggested that neuronavigated high-frequency rTMS at left DLPFC is effective for depression, anxiety, and motor symptoms in PD patients.

• 单位
  南方医科大学; 广东省人民医院