Transcription factor EB: A potential integrated network regulator in metabolic-associated cardiac injury

作者：Wen, Weixing; Zheng, Haoxiao; Li, Weiwen; Huang, Guolin; Chen, Peng; Zhu, Xiaolin; Cao, Yue; Li, Jiahuan; Huang, Xiaohui; Huang, Yuli^*

来源：Metabolism: Clinical and Experimental , 2023, 147: 155662.

DOI：10.1016/j.metabol.2023.155662

• Autophagy
• Lipid metabolism
• Endothelial dysfunction
• Mitochondrial quality control

its role in regulating lysosomal biogenesis and autophagy. Recently, the regulatory role of TFEB in other bio-logical processes, including the regulation of glucose homeostasis, lipid metabolism, etc. has been gradually revealed. In this review, we will focus on the relationship between TFEB and IR, lipid metabolism, endothelial dysfunction, oxidative stress, inflammation, ERS, calcium homeostasis, autophagy, and mitochondrial quality control (MQC) and the potential regulatory mechanisms among them, to provide a comprehensive summary for TFEB as a potential new therapeutic target for CMD.

• 单位
  南方医科大学; 1