科研之友
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摘要
As one of the most ancient traditional Chinese medicines, Glycyrrhiza uralensis Fisch shows definite curative impact on many diseases. This study aims to evaluate the influence of Glycyrrhiza uralensis Fisch extract on cariogenic factors of S. mutans. These data suggested that MIC of Glycyrrhiza uralensis Fisch extract against planktonic cells was 8 mg/mL.The extract at sub-MIC levels had a repressive effect on acid production of S. mutans. Glycyrrhiza uralensis Fisch extract inhibitd the initial adhesion stage of biofilm formation. Although Glycyrrhiza uralensis Fisch extract had no effect on mature biofilm removal, it could partly penetrate through the biofilm and kill the bacterial cells. These results indicate that Glycyrrhiza uralensis Fisch extract has a suppressive impact on cariogenic factors of S. mutans and it represents a promising anti-caries agent.
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单位云南大学
