Biodegradable polymer network encapsulated polyplex for DNA delivery

作者:Petrov P D*; Ivanova N I; Apostolova M D; Tsvetanov C B
来源:RSC Advances, 2013, 3(11): 3508-3511.
DOI:10.1039/c3ra21890b

摘要

A novel gene delivery system is made by encapsulation of a polyplex between pDNA and cationic micelles with a biodegradable crosslinked shell. The outer shell can provide additional functionality to the system and protect DNA from degradation. The encapsulated polyplex exhibits a similar transfection efficiency compared to the naked polyplex.

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