Research Advances on Proteinase 3 and Its Relationship With Diseases

作者：Liu Guang Hua; Deng Li; Peng Li Fei^*

来源：Progress in Biochemistry and Biophysics, 2015, 42(3): 244-253.

DOI：10.16476/j.pibb.2014.0266

• proteinase 3
• cytokine
• inhibitor
• inflammatory disease
• granulomatosis with polyangiitis
• chronic obstructive pulmonary diseases
• pulmonoary fibrosis

Proteinase 3 is one of the major serine proteases secreted by neutrophils with multiple biological functions. It can degradate tissue proteins, process cytokines and receptors, thus contributing to the regulation of inflammatory and immune responses, and play important roles in the occurrence and development of chronic inflammatory diseases, such as granulomatosis with polyangiitis, chronic obstructive pulmonary diseases and pulmonoary fibrosis. In this reviews, we describle the biological functions of PR3 and its roles in human diseases, which might provide a new insight for the prevention and treatment of human diseases.

• 单位
  广东医学院