The Effects of Drug Exposure and Single Nucleotide Polymorphisms on Aaptinib-Induced Severe Toxicities in Solid Tumors

作者：Chen, Youhao; Lin, Yaobin; Guan, Shaoxing; Zhao, Zerui; Lin, Daren; Guan, Jin; Zhou, Chengzhi; Liu, Junling; Cao, Xiaolong; Lin, Zhichao; Chen, Diyao; Shang, Jianbiao; Zhang, Weijian; Chen, Huohui; Chen, Likun; Ma, Shudong; Gu, Lijia; Zhao, Jian; Huang, Min^*; Wang, Xueding^*; Long, Hao^*

来源：Drug Metabolism and Disposition, 2023, 51(12): 1583-1590.

DOI：10.1124/dmd.123.001428

• CELL LUNG-CANCER
• ENDOTHELIAL GROWTH-FACTOR
• PHASE-III TRIAL
• WILD-TYPE EGFR
• INDUCED HYPERTENSION
• 1ST-LINE TREATMENT
• CLINICAL-TRIAL
• APATINIB
• BEVACIZUMAB
• SORAFENIB

To investigate the value of drug exposure and host germline genetic factors in predicting apatinib (APA)-related toxicities.Method: In this prospective study, plasma APA concentrations were quantified using liquid chromatography with tandem mass spectrometry, and 57 germ line mutations were genotyped in 126 advanced solid tumor patients receiving 250 mg daily APA, a vascular endothelial growth factor receptor II inhibitor. The correlation between drug exposure, genetic factors, and the toxicity profile was analyzed.Results: Non-small cell lung cancer (NSCLC) was more prone to APA-related toxicities and plasma concentrations of APA, and its main metabolite M1-1 could be associated with high-grade adverse events (AEs) (P < 0.01; M1-1, P < 0.01) and high-grade antiangiogenetic toxicities (APA, P 5 0.034; P < 0.05), including hypertension, proteinuria, and hand-foot syndrome, in the subgroup of NSCLC. Besides, CYP2C9 rs34532201 TT carriers tended to have higher levels of APA (P < 0.001) and M1-1 (P < 0.01), whereas CYP2C9 rs1936968 GG carriers were predisposed to higher levels of M1-1 (P < 0.01).Conclusion: Plasma APA and M1-1 exposures were able to predict severe AEs in NSCLC patients. Dose optimization and drug exposure monitoring might need consideration in NSCLC patients with CYP2C9 rs34532201 TT and rs1936968 GG.

• 单位
  中山大学; 广州医学院; 南方医科大学; 佛山市第一人民医院; 1