Effects of combination docetaxel with NO treatment to enhance the anti-nasopharyngeal carcinoma efficiency in vitro and in vivo

作者：Xu, Lingling; Wu, Xidong; Liu, Huiqin; Dong, Guangyuan; Zhan, Jiandong; Li, Guanxue; Wang, Guanhai^*; Liu, Tao^*

来源：European Journal of Pharmaceutical Sciences, 2022, 178: 106281.

DOI：10.1016/j.ejps.2022.106281

• Docetaxel
• JS-K
• Drug combination
• Nitric oxide
• Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is one of the major causes of death in Southern China. Due to the insidious location of NPC, the therapeutic effect of locoregionally advanced NPC is still unsatisfactory. In this work, to improve the treatment efficiency, combining DOC and JS-K to inhibit NPC cells (HNE-1) in vitro was investigated, as well as its possible mechanisms. Moreover, the in vivo effects of DOC and JS-K combination treatment were also evaluated in a xenograft model with HNE-1 cells. In vitro experiments including cell proliferation, migration ability, apoptosis, and expression levels of apoptosis-associated proteins revealed that the combination of DOC and JS-K was able to enhance antitumor effects. In vivo results further confirmed a significant treatment effect without obvious toxicity on mice. The present work provides a promising idea for the treatment of locally advanced NPC.

• 单位
  广东省人民医院; 广东医学院; 汕头大学; 南方医科大学