Emerging Trends in Copper-Promoted Radical-Involved C-O Bond Formations

作者：Wang, Peng-Zi; Chen, Jia-Rong^*; Xiao, Wen-Jing^*

来源：Journal of the American Chemical Society, 2023, 145(32): 17527-17550.

DOI：10.1021/jacs.3c04879

• CATALYZED AMINOOXYGENATION
• N-HYDROXYPHTHALIMIDE
• UNACTIVATED ALKENES
• ENANTIOSELECTIVE SYNTHESIS
• ALLYLIC OXIDATION
• CENTERED RADICALS
• ELECTRON-TRANSFER
• MOLECULAR-OXYGEN
• SATURATED OXYGEN
• CARBOXYLIC-ACIDS

The C-O bond is ubiquitous in biologically activemolecules,pharmaceutical agents, and functional materials, thereby making itan important functional group. Consequently, the development of C-Obond-forming reactions using catalytic strategies has become an increasinglyimportant research topic in organic synthesis because more conventionalmethods involving strong base and acid have many limitations. In contrastto the ionic-pathway-based methods, copper-promoted radical-mediatedC-O bond formation is experiencing a surge in research interestowing to a renaissance in free-radical chemistry and photoredox catalysis.This Perspective highlights and appraises state-of-the-arttechniques in this burgeoning research field. The contents are organizedaccording to the different reaction types and working models.

• 单位
  兰州大学