科研之友
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摘要
A novel base-promoted and highly efficient strategy for preparation of trifluoromethyl-containing tetrasubstituted olefin derivatives has been developed. The trifluoroacetyl amination of alkynes is realized by C-N cleavage of trifluoroacetamides without any transition-metal catalysts. Readily accessible substrates, good functional group tolerance and atom economy make this approach attractive for the synthesis of trifluoromethyl-containing tetrasubstituted olefins.
