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摘要
Rationale & Objective: Challenges in achieving valid risk prediction and stratification impede treatment decisions and clinical research design for patients with glomerular diseases. This study evaluated whether chronic histologic changes, when complementing other clinical data, improved the prediction of disease outcomes across a diverse group of glomerular diseases. @@@ Study Design: Multicenter retrospective cohort study. @@@ Setting & Participants: 4,982 patients with biopsy-proven glomerular disease who underwent native biopsy at 8 tertiary care hospitals across China in 2004-2020. @@@ New Predictors & Established Predictors: Chronicity scores depicted as 4 categories of histological chronic change, as well as baseline clinical and demographic variables. @@@ Outcome: Progression of glomerular disease defined as a composite of kidney failure or a >= 40% decrease in estimated glomerular filtration rate from the measurement at the time of biopsy. @@@ Analytical Approach: Multivariable Cox proportional hazard models. The performance of predictive models was evaluated by C statistic, time-dependent area under the receiver operating characteristic curve (AUROC), net reclassification index, integrated discrimination index, and calibration plots. @@@ Results: The derivation and validation cohorts included 3,488 and 1,494 patients, respectively. During a median of 31 months of followup, a total of 444 (8.9%) patients had disease progression in the 2 cohorts. For prediction of the 2- year risk of disease progression, the AUROC of the model combining chronicity score and the Kidney Failure Risk Equation (KFRE) in the validation cohort was 0.76 (95% CI, 0.65-0.87); in comparison with the KFRE model (AUROC, 0.68 [95% CI, 0.56-0.79]), the combined model was significantly better (P = 0.04). The combined model also had a better fit, with a lower Akaike information criterion and a significant improvement in reclassification as assessed by the integrated discrimination improvements and net reclassification improvements. Similar improvements in predictive performance were observed in subgroup and sensitivity analyses. @@@ Limitations: Selection bias, relatively short follow-up, lack of external validation. @@@ Conclusions: Adding histologic chronicity scores to the KFRE model improved the prediction of kidney disease progression at the time of kidney biopsy in patients with glomerular diseases.
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单位中山大学; 浙江大学; 南方医科大学
