Two new resin glycosides from Calystegia sepium (L.) R. Br. with potential antitumor activity

作者：Liang, Huixian; Hu, Jiayan; Li, Zhitong; Yin, Yongqin^*

来源：Journal of Molecular Structure, 2022, 1257: 132636.

DOI：10.1016/j.molstruc.2022.132636

• Resin glycosides
• Structural identification
• Calyhedic acid A and B
• Calystegia sepium (L) R.& nbsp
• Br
• Docking

Two new resin glycosides named calystegins A-B ( 1-2 ), together with seven known compounds ( 3-9) were isolated from the aerial parts of Calystegia sepium (L.) R. Br (Convolvulaceae). The calystegins were macrolactones of calyhedic acid A or calyhedic acid B, which were esterified partially with different fatty acids. The lactonization site of aglycone and jalapinolic acid, were located at C-2 of the second or third glucoses, respectively. Their structures were thoroughly characterized by extensive spectroscopic analyses as well as chemical evidence. Molecular docking studies revealed that compound 1 and 2 were successfully localized in the binding pocket of a, fi-tubulin in zinc-stabilized sheets (AGb =-4.68, 4.75 kcal/mol).

• 单位
  广东药学院