Effect of pressure on the stability of G-quadruplex DNA: Thermodynamics under crowding conditions

摘要

Under pressure: A DNA G-quadruplex was unfolded under high pressure, but crowding conditions repressed this effect owing to enthalpic contributions. Volumetric analysis showed that ethylene glycol or poly(ethylene glycol) decreased the volume change of the transition by more than fourfold owing to the alteration of the number and/or radii of hydrating water molecules.

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