Development and characterisation of a novel krill oil nanostructured lipid carrier based on 1,3-glycerol distearate

Authors：Lin, Yunwei; Yin, Wenting; Liu, Guoqin^*

Source：International Journal of Food Science and Technology, 2020, 55(11): 3493-3502.

DOI：10.1111/ijfs.14683

• 1
• 3-glycerol distearate
• Antarctic krill oil
• nanostructured lipid carriers
• particle size
• polydispersity index

A novel nanostructured lipid carrier (NLC) loaded with Antarctic krill oil while using 1,3-glycerol distearate (GDS) as the solid lipid was prepared through ultrasonication. The NLCs were optimised for ingredient formulation by single-factor experiment on the basis of their effects on the particle size and polydispersity index (PDI) of the NLCs. 2% (w/w) lecithin and 10% lipid phase of which krill oil accounted for 50% (w/w) were applied to develop the optimised NLC dispersion. The particle size, PDI and zeta potential of this NLC were 112 nm, 0.270 and -30.8 mV, respectively, indicating good dispersion uniformity and stability. Transmission electron microscopy (TEM) revealed that the optimised NLC particles were spherical and uniformly dispersed without apparent aggregation. Differential calorimetry scanning (DSC) and X-ray diffraction (XRD) showed that the optimised NLC had less-ordered crystalline structure contributing to the high entrapment efficiency (> 99%) of EPA and DHA.

• Institution
  河南工业大学