Low-Temperature Photothermal Therapy Based on Borneol-Containing Polymer-Modified MXene Nanosheets

作者：Yang, Liu; Chen, Siyu; Wei, Hongxin; Luo, Yinzhu; Cong, Feng; Li, Wende; Hong, Liangzhi^*; Su, Jianyu^*

来源：ACS applied materials & interfaces, 2022, 14(40): 45178-45188.

DOI：10.1021/acsami.2c12839

• low-temperature photothermal therapy
• MXenes
• borneol
• membrane targeting
• antibacterial activity

Noninvasive photothermal therapy (PTT) is an emerging strategy for eliminating multidrug-resistant (MDR) bacteria that achieve sterilization by generating temperatures above 50 degrees C; however, such a high temperature also causes collateral damage to healthy tissues. In this study, we developed a low-temperature PTT based on borneol-containing polymer-modified MXene nanosheets (BPM) with bacteria-targeting capabilities. BPM was fabricated through the electrostatic coassembly of negatively charged two-dimensional MXene nanosheets (2DM) and positively charged quaternized alpha-(+)-borneol-poly(N, N-dimethyl ethyl methacrylate) (BPQ) polymers. Integrating BPQ with 2DM improved the stability of 2DM in physiological environments and enabled the bacterial membrane to be targeted due to the presence of a borneol group and the partially positive charge of BPQ. With the aid of near-infrared irradiation, BPM was able to effectively eliminate methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) through targeted photothermal hyperthermia. More importantly, BPM effectively eradicated more than 99.999% (>5 orders of magnitude) of MRSA by localized heating at a temperature that is safe for the human body (<= 40 degrees C). Together, these findings suggest that BPM has good biocompatibility and that membrane-targeting low-temperature PTT could have great therapeutic potential against MDR infections.