Case report: Deterioration of infantile hemangioma related to oral or nebulized administration of β2-AR agonist: Three cases reports

作者：Chen, Qiang; Zhang, Yunxuan; Sun, Chenyu; Liu, Li; Luo, Xiaoyan; Wang, Hua; Ni, Sili^*

来源：Frontiers in Oncology, 2022, 12: 1000099.

DOI：10.3389/fonc.2022.1000099

• infantile hemangioma
• recurrence
• propranolol
• beta 2-adrenergic receptor
• salbutamol
• procaterol

Infantile hemangioma (IH) is a benign vascular tumor, characterized by a unique sequence of non-linear growth and spontaneous involution. Some hemangiomas require intensive treatment to avoid functional and aesthetic insufficiency. Although beta-adrenergic receptor (beta-AR) antagonists have been increasingly used as the first-line treatment since 2008, the IH rebound still exists with uncertain mechanism. Here, we report three cases of abrupt IH deteriorations that are mainly related to beta 2-AR agonist administration. Potential IH proliferation induced by beta 2-AR agonists, especially from oral or nebulized approaches, should be recognized more widely by healthcare providers. Additionally, it is necessary to carry out large sample studies to analyze the influence of beta 2-AR agonist administration on the deterioration of IH.