A new type of cuprous-cysteamine sensitizers: Synthesis, optical properties and potential applications

作者：Wang, Y.; Alkhaldi, N. D.; Pandey, N. K.; Chudal, L.; Wang, L. Y.; Lin, L. W.; Zhang, M. B.^*; Yong, Y. X.; Amador, E. H.; Huda, M. N.^*; Chen, W.^*

来源：Materials Today Physics, 2021, 19: 100435.

DOI：10.1016/j.mtphys.2021.100435

• Cuprous-cysteamine
• Sensitizer
• Luminescence
• Reactive oxygen species
• Photodynamic therapy
• Microwave
• Singlet oxygen
• Density functional theory (DFT)

Herein, for the first time, we report a series of cuprous-cysteamine (Cu-Cy-X, X = F, Cl, Br, and I)) sensitizers that possess tunable fluorescence from orange to yellow. The Cu-Cy-X can generate reactive oxygen species (ROS), including singlet oxygen (O-1(2)) in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl approximate to Cu-Cy-F under UV and microwave excitation. Further study revealed that Cu-Cy-X has stability in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl approximate to Cu-Cy-F. In this work, a detailed synthesis technique, crystal structure, optical properties, and mechanism of the observed trend in O-1(2) generation, luminescence spectra, and anticancer effect are discussed in both theoretical and experimental points of view. These new materials will open a new door for photodynamic therapy and many other potential applications such as sensing, lighting, displays, labeling, and medical imaging.

• 单位
  桂林理工大学