Effectiveness of low frequency electrical stimulation for radical hysterectomy women: systematic review and meta-analysis

作者：Liu, Ye; Li, Mei-fei; Li, Meng-yuan; Chen, Innie; Xie, Ri-hua; Yan, Xiao-ying^*

来源：Frontiers in Bioengineering and Biotechnology, 2022, 10: 1041295.

DOI：10.3389/fbioe.2022.1041295

• Cervical cancer
• radical hysterectomy
• low frequency electrical stimulation
• urinary retention

Introduction: To explore the effects of low frequency electrical stimulation (LFES) in preventing urinary retention (UR) after radical hysterectomy (RH) in women with cervical cancer. Methods: Seven electronic bibliographic databases were searched from inception to December 25, 2021. The mean difference (MD) or risk ratio (RR) with its corresponding 95% CI were selected as effect size. The meta analysis of all data was conducted using RevMan 5.4 and the evidence was summarized according to GRADE (the grading of recommendation, assessment, development and evaluation). Results: Twelve RCTs consisting of 1033 women with cervical cancer who had undergone radical hysterectomy were included. Compared with women in the control group, women receiving LFES had improved therapeutic effect (RR=0.22,95%CI 0.16 to 0.29), and reduced residual urine volume (MD =-32.27, 95%CI-34.10 to-30.43) and catheter retention time (MD =-4.46, 95%CI-5.17 to-3.76) following treatment. Muscle strength scores of pelvic floor type I and type II muscle fibers in the LFES group were also higher than in the control group (MD =1.07, 95%CI 0.91 to 1.24). Conclusion: LFES may be an effective auxiliary treatment for women with cervical cancer after hysterectomy, which can help reduce the duration of indwelling urethral catheter and residual urine volume.

• 单位
  南方医科大学; 广东药学院