The application research on Cu-Al@SBA-15 bimetallic synergistic effect in the C-X bond sequential assembly

作者：Pei, Mengyu; Luo, Xianghao; Tang, Quan; Huang, Nianyu; Wang, Long^*

来源：Catalysis Communications, 2022, 172: 106548.

DOI：10.1016/j.catcom.2022.106548

• Sequentially assembled
• The coupling reaction
• The synergistic effect
• 2-substituted benzothiazole
• Bimetallic heterogeneous mesoporous material

The coupling reaction allows simple structural fragments to be constructed and sequentially assembled by C-X bond to synthesize a variety of active molecular frameworks. Different from the traditional single-metal catalyst, the synergistic effect of bimetal provides special catalytic activity that cannot be obtained by traditional single -metal catalyst, thus emerging as an efficient alternative mode. In this paper, we used Cu-Al bimetallic heterogeneous mesoporous materials to participate in the sequential assembly of C-S and C-N bonds, which effectively catalyzed the synthesis of 2-substituted benzothiazole heterocyclic systems. In addition, GW610 with antitumor activity was synthesized easily and efficiently by this strategy.