Association of anhedonia and suicidal ideation in patients with treatment-refractory depression after intravenous ketamine infusions

作者：Zheng, Wei; Gu, Li-Mei; Yang, Xin-Hu; Zhou, Yan-Ling; Wang, Cheng-Yu; Lan, Xiao-Feng; Zhang, Bin; Ning, Yu-Ping^*

来源：INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 2023, 27(2): 145-150.

DOI：10.1080/13651501.2022.2138444

• Ketamine
• Montgomery-angstrom sberg Depression Rating Scale
• anhedonia
• suicidal ideation
• depression
• clinical trial

Objectives: Accumulating evidence suggests that the effects of ketamine administered intravenously at subanaesthetic doses on both anhedonic symptoms and suicidal ideation occur independently of depressive symptoms in major depressive disorder (MDD) and bipolar disorder (BD). This study sought to determine the relationship between anhedonia and suicidal ideation after serial ketamine infusions. @@@ Methods: A total of 79 subjects with either treatment-refractory MDD (n = 60) or BD (n = 19) were included in a clinical ketamine study. The Montgomery-angstrom sberg Depression Rating Scale (MADRS) anhedonia factor and the first five items of the Scale for Suicidal Ideations (SSI-Part I) were used to assess anhedonia symptoms and suicidal ideation, respectively. @@@ Results: At baseline, anhedonia, as measured by the MADRS, was not significantly associated with suicidal ideation or specific suicide-related ideation as measured by SSI-Part I (all p's > 0.05). Only the 'wish to die' and 'desire to make a suicide attempt' items were positively associated with anhedonia at two weeks after the sixth ketamine infusion, which was independent of the reductions in depressive symptoms (all p's < 0.05). @@@ Conclusion: Anhedonia as measured by the MADRS appeared to not be positively related to suicidal ideation after serial ketamine infusions.

• 单位
  1; 广州医学院; 南方医科大学