(±)-Heterocageflavone, anti-inflammatory isoprenylated flavonoids with a tricyclo[5.3.1.03,8]undecane moiety from Artocarpus heterophyllus

作者：Ren, Gang; Gan, Li-She; Zhu, Ling-Zhi; Zeng, Hui-Ting; Xu, Fan; Yuan, Tao^*

来源：Bioorganic Chemistry, 2022, 123: 105742.

DOI：10.1016/j.bioorg.2022.105742

• Artocarpus heterophyllus
• Isoprenylated flavonoids
• Enantiomeric
• Anti-inflammatory

(+/-)-Heterocageflavone (1), a pair of enantiomeric isoprenylated flavonoids, were isolated from Artocarpus heterophyllus. Compound 1 incorporates an unusual tricyclo[5.3.1.0(3,8)]undecane moiety, forming a unique caged polycyclic system. The structures of the pair were determined by spectroscopic analysis, ECD calculations, and single-crystal X-ray diffraction. Compound 1 showed significant inhibitory activity against LPS-induced NO production in RAW264.7 cells with an IC50 value of 49.2 mu M.

• 单位
  浙江大学