Alpha-Synuclein: The Interplay of Pathology, Neuroinflammation, and Environmental Factors in Parkinson's Disease

作者：He, Songzhe; Zhong, Shan; Liu, Gang; Yang, Jun^*

来源：Neurodegenerative Diseases, 2021, 20(2-3): 55-64.

DOI：10.1159/000511083

• alpha-Synuclein
• Parkinson's disease
• Protein aggregation
• Neuroinflammation
• Environmental factors

Background: Parkinson's disease (PD) is a multifactorial, chronic, and progressive neurodegenerative disease. alpha-Synuclein (alpha-syn), which is the main protein component of Lewy bodies, plays an important role in the pathological hallmarks of PD. However, the pathological function of alpha-syn and the molecular mechanisms responsible for the degeneration of dopaminergic neurons are still elusive. Summary: Cumulative evidence implicates that abnormal processing of alpha-syn will be predicted to lead to pathological changes in PD. Key Messages: In this review, we summarize the structure and physiological function of alpha-syn, and further discuss the interplay of pathology, neuroinflammation, and environmental factors in PD. Additionally, we suggest future directions for understanding the toxicity of alpha-syn to neurons, which may ultimately encourage us to better design disease-modifying therapeutic strategies for PD.

• 单位
  南方医科大学