Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina

作者：Kong, Kangjie; Wang, Peiyuan; Xie, Zihong; Wang, Lu; Jiang, Jiaxuan; Liu, Yaoming; Du, Shaolin; Jiang, Jingwen; Song, Yunhe; Lin, Fengbin; Wang, Wei; Fang, Xiuli; Shi, Zhuoxing^*; Zhang, Xiulan^*; Chen, Shida^*

来源：Scientific Data, 2023, 10(1): 653.

DOI：10.1038/s41597-023-02562-9

• EXPRESSION ANALYSIS
• PHOTORECEPTORS
• PACKAGE
• HISAT

Mice have emerged as a widely employed model for investigating various retinal diseases. However, the availability of comprehensive datasets capturing the entire developmental and aging stages of the mouse retina, particularly during the elderly period, encompassing integrated lncRNA and mRNA expression profiles, is limited. In this study, we assembled a total of 18 retina samples from mice across 6 distinct stages of development and aging (5 days, 3 weeks, 6 weeks, 10 weeks, 6 months, and 15 months) to conduct integrated lncRNA and mRNA sequencing analysis. This invaluable dataset offers a comprehensive transcriptomic resource of mRNA and lncRNA expression profiles during the natural progression of retinal development and aging. The discoveries stemming from this investigation will significantly contribute to the elucidation of the underlying molecular mechanisms associated with various retinal diseases, such as congenital retinal dysplasia and retinal degenerative diseases. @@@ Design Type(s)organism development and aging design & BULL; transcriptional profiling by RNA sequencing designMeasurement Type(s)long noncoding RNA and mRNA profiling assayTechnology Type(s)illumina RNA sequencingFactor Type(s)life cycle stageSample Characteristic(s)Mus musculus & BULL; retina

• 单位
  中国科学院; 广州医学院; 广州中医药大学; 中山大学