Interferon alpha serum level association with low vitamin D levels in Chinese patients with primary Sjogren's syndrome

作者：Zheng, Muhan; Zhu, Shijie; Li, Yang; Chen, Jianhui; Lai, Weinan^*

来源：European Journal of Inflammation, 2021, 19.

DOI：10.1177/20587392211014053

• Chinese population
• disease activity
• interferon alpha
• primary Sjogren's Syndrome
• vitamin D

The purpose of this retrospective cross-sectional study was to explore the clinical and pathogenic significance of vitamin D and its relationship with interferon-a (IFN-alpha) in Chinese patients with primary Sjogren's syndrome (pSS). In our study, 32 pSS patients and 50 healthy controls were included. Serum vitamin D and IFN-a concentrations were determined by enzyme-linked immunosorbent assay (ELISA) and analyzed with the correlations of EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI). The multiple linear regression analysis of 25-OH vitamin D3 level with ESSDAI scores in pSS patients was also investigated. Serum 25-OH vitamin D3 significantly correlated in an inverse manner with ESSDAI scores (p < 0.001, r = -0.781) and IgG (p < 0.001, r = -0.64). Serum 25-OH vitamin D3 were only related to peripheral nervous system (PNS) domain deficiency. Further, serum IFN-alpha was positively correlated with ESSDAI, but negatively correlated with serum 25-OH vitamin D3. These results suggest an important role of vitamin D regulating disease activity in pSS patients and value of supplement vitamin D in pSS treatment.

• 单位
  中山大学; 南方医科大学