Rationally designed Ru(ii) metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer

作者：Tu, Le; Li, Chonglu; Liu, Chang; Bai, Suya; Yang, Jingfang; Zhang, Xian; Xu, Liying^*; Xiong, Xiaoxing^*; Sun, Yao^*

来源：Chemical Communications, 2022, 58(65): 9068-9071.

DOI：10.1039/d2cc03118c

• POLYPYRIDYL COMPLEXES
• COORDINATION
• CONSTRUCTION
• METALLACAGES

Herein, we construct a series of Ru(ii) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting apoptosis. These results open new possibilities for Ru(ii) metallacycles in biomedicine.

• 单位
  y; 武汉大学