Synthesis of arylboronates via the Pd-catalyzed desulfitative coupling reaction of sodium arylsulfinates with bis(pinacolato)diboron

Authors：Qiu, Di^*; Li, Songyi; Yue, Guanglu; Mao, Jinshan; Xu, Bei; Yuan, Xinyu; Ye, Fei^*

Source：2021, 85: 153478.

DOI：10.1016/j.tetlet.2021.153478

• Palladium catalysis
• Desulfitative
• Cross-coupling
• Sodium arylsulfinates
• Arylboronate

The desulfitative borylation reaction of sodium arylsulfinates with bis(pinacolato)diboron or bis(-neopentylglycolato)diboron under palladium catalysis has been developed, allowing selective C-B bond formation to give arylboronates with a range of functional groups in moderate to good yields under mild reaction conditions. A gram-scale preparation as well as the cascade Suzuki-Miyaura cross-coupling of arylboronates demonstrated the potential practical utility in organic synthesis.