Synthesis, Characterization of Rare Earth Complexes with Succinic Acid and 1,10-Phenanthroline and Interacting with DNA

摘要

Rare earth complexes with succinic acid and 1 ,10-phenanthroline were synthesized first-ly and the interaction with DNA was investigated by spectroscopy method, which provide the basis for the design and development of new anticancer drugs. Three kinds of ternary complexes of rare earth(La3+,Nd3+,Eu3+) with succinic acid (SA) and 1,10-phenanthroline (phen) were synthe-sized in absolute ethanol solution, which were characterized by eleme-ntal analysis, IR, UV-Vis and TG-DTA methods. The compositions of the complexes were confirmed to be (RE)2(SA)(phen)· 2H2O (RE =La, Nd, Eu). Meanwhile, the interactions between complexes and herring sperm DNA have been investigated by electronic absorption spectrum and fluorescence spectrum. The UV absorption spectra showed that the maximal absorption peaks intensity of complexes was weakened with the adding of DNA, and accompanied by a red shift. The combining ratio, binding constant of complex to DNA was obtained and the corresponding thermodynamic parameters were calculated,showed that the interaction between complex and hsDNA was driven mainly by entropy. All the above indicated that the interaction mode of the complexes with DNA belonged to intercalative.

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