A Comparative Study of 18F-FAPI-42 and 18F-FDG PET/CT for Evaluating Acute Kidney Injury in Cancer Patients

作者：Chi, Xiaohua; Yang, Xiaoqiang; Li, Guiping; Wu, Hubing; Huang, Jiawen; Qi, Yongshuai; Tang, Ganghua^*

来源：MOLECULAR IMAGING AND BIOLOGY, 2023, 25(4): 671-680.

DOI：10.1007/s11307-023-01820-x

• FAPI
• fibroblast activation protein inhibitor
• FDG
• fluorodeoxyglucose
• AKI
• acute kidney injury
• UO
• ureteral obstruction
• PET
• CT

PurposeCompare the value of imaging using positron F-18-labeled fibroblast activation protein inhibitor-42 (F-18-FAPI-42) and F-18-labeled deoxyglucose (F-18-FDG) for assessment of AKI.ProceduresThis study analyzed cancer patients who received F-18-FAPI-42 and F-18-FDG PET/CT imaging. Eight patients had AKI with bilateral ureteral obstruction (BUO), eight had BUO (CKD1-2) with no acute kidney disease (AKD), and eight had no ureteral obstruction (UO) with normal renal function. The average standardized uptake value (SUVave) of the renal parenchyma (RP-SUVave), the blood pool SUVave (B- SUVave), SUVave in the highest region of the renal collective system (RCS-SUVave), and the highest serum creatinine level (top SCr) were recorded.ResultsThe F-18-FAPI-42 and F-18-FDG results showed that radiotracer of renal parenchyma was more concentrated in the AKI group than in the other two groups, whereas the RP-SUVave from F-18-FAPI-42 was higher than that from F-18-FDG in the AKI group (all P < 0.05). F-18-FAPI-42 imaging in the AKI group showed uptake by the renal parenchyma with a diffuse increase, but very little radiotracer in the renal collecting system, similar to a "super kidney scan." The renal parenchyma also had an increase of SUVave, with accumulation of radiotracer in the renal collecting system. AKI was more severe when a patient had a "super kidney scan" in both kidneys (P < 0.05). The B-SUVave level was higher in the AKI group than in the other two groups in F-18-FAPI-42 (both P < 0.05).Conclusions(18)F-FAPI-42 imaging had higher RP-SUVave than F-18-FDG imaging in cancer patients who had BUO with AKI. An increased renal parenchyma uptake in both kidneys and low radiotracer distribution in the collecting system suggest more severe AKI.

• 单位
  南方医科大学