B(C6F5)3-catalyzed tandem protonation/deuteration and reduction of in situ-formed enamines

摘要

A highly efficient B(C6F5)(3)-catalyzed tandem protonation/deuteration and reduction of in situ-formed enamines in the presence of water and pinacolborane was developed. Regioselective beta-deuteration of tertiary amines was achieved with high chemo- and regioselectivity. D2O was used as a readily available and cheap source of deuterium. Mechanistic studies indicated that B(C6F5)(3) could activate water to promote the protonation and reduction of enamines.

关键词