METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

Authors：Canfeng Zhang; Liping Chen; Di Peng; Ao Jiang; Yunru He; Yanru Zeng; Chen Xie; Haoxian Zhou; Xiaotong Luo; Haiying Liu; Liang Chen; Jian Ren; Wengong Wang; Yong Zhao

Source：Molecular Cell, 2020.

DOI：10.1016/j.molcel.2020.06.017

• METTL3
• m6A
• ATM
• DDR
• DSB
• homologous recombination
• DNA-RNA hybrids
• YTHDC1
• genome stability
• cancer therapy

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