The rs41291957 polymorphism of miR-143/145 and cancer risk: a case-control study and meta-analysis

作者：Feng, Lei^*; Jin, Yuchen; Chai, Longlong; Xiong, Weining; Wang, Weiyi; Feng, Xianhong; Chen, Bifeng^*

来源：Nucleosides, Nucleotides and Nucleic Acids, 2023, 42(6): 478-494.

DOI：10.1080/15257770.2022.2157436

• miR-143
• 145 cluster
• rs41291957
• cancer risk
• meta-analysis

Recently, the rs41291957 polymorphism in the promoter region of miR-143/145 has been repeatedly investigated for its contribution to cancer susceptibility. However, the results remain conflicting rather than conclusive, which calls for further investigations. Therefore, we here conducted a case-control study and meta-analysis to explore the association between rs41291957 and cancer risk. In the case-control study, a total of 2277 cancer patients (lung, liver, gastric and colorectal cancers) and 800 normal controls were recruited, the genotyping of rs41291957 was performed with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Sanger sequencing. In the meta-analysis, 5 previously published studies and our present study were included, the STATA 14.0 software was applied to conduct all statistical analyses. The results of case-control study showed that rs41291957 was significantly associated with the risk of gastric cancer, colon cancer, rectal cancer, and colorectal cancer in Hubei Han Chinese population. The results of meta-analysis demonstrated that rs41291957 was significantly associated with overall cancer risk, especially colorectal cancer risk and lung cancer risk. Collectively, the rs41291957 polymorphism of miR-143/145 may be a plausible susceptible locus for cancer risk, which should be validated in future studies with larger samples in different ethnic populations.

• 单位
  武汉理工大学