C/EBP beta knockdown protects cardiomyocytes from hypertrophy via inhibition of p65-NF kappa B

作者：Zou Jian; Li Hong; Chen Xi; Zeng Siyu; Ye Jiantao; Zhou Changhua; Liu Min; Zhang Luankun; Yu Na; Gan Xiaohong; Zhou Houfeng; Xian Zhiwei; Chen Shaorui^*; Liu Peiqing

来源：Molecular and Cellular Endocrinology, 2014, 390(1-2): 18-25.

DOI：10.1016/j.mce.2014.03.007

• C/EBP beta
• p65-NF kappa B
• Cardiac hypertrophy

C/EBP beta, a member of the bHLH gene family of DNA-binding transcription factors, has been indicated as a central signal in physiologic hypertrophy. However, the role of C/EBP beta in pathological cardiac hypertrophy remains to be elucidated. In this study, we revealed that C/EBP beta is involved in cardiac hypertrophy, the expression of C/EBP beta were significantly increased in response to hypertrophic stimulation in vitro and in vivo. C/EBP beta knockdown inhibited PE-induced cardiac hypertrophy, and diminished the nuclear translocation and DNA binding activity of p65-NF kappa B. These results suggested that C/EBP beta knockdown protected cardiomyocytes from hypertrophy, which may be attributed to inhibition of NF kappa B-dependent transcriptional activity. These findings shed new light on the understanding of C/EBP beta-related cardiomyopathy, and suggest the potential application of C/EBP beta inhibitors in cardiac hypertrophy.

• 单位
  广东省第二人民医院