A ratiometric fluorescent probe based on AIEgen for detecting HClO in living cells

作者：Zhang, Weijie; Wang, He; Li, Feng; Chen, Yuncong; Kwok, Ryan T. K.; Huang, Yuhua^*; Zhang, Jianglei^*; Hou, Jianquan^*; Tang, Ben Zhong^*

来源：Chemical Communications, 2020, 56(93): 14613-14616.

DOI：10.1039/d0cc06582j

• ENDOGENOUS HYPOCHLOROUS ACID
• CANCER-CELLS
• MYELOPEROXIDASE
• MITOCHONDRIA
• GENERATION
• STRESS
• SENSOR
• HOCL

A new ratiometric fluorescent probe, namely TPE-RNS, has been developed for detecting intracellular HClO/ClO- in living cells and discriminating cancer cells from normal cells. Based on the ratiometric fluorescence properties conferred by the AIE and DTBET effects, this probe has excellent sensitivity and specificity for the HCIO response.

• 单位
  南京大学; 苏州大学; 1