Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine

作者：Wu, Yu; Li, Nannan; Zhang, Tao; Che, Yanyun; Duan, Kun; Wang, Yuedi; Zhou, Hui; Wan, Xin; Lei, Hongjun; Nguyen, Audrey D.; De Souza, Cristabelle; Li, Kun; Wu, Yi; Liu, Jiaguo; Wang, Deyun

来源：Poultry Science, 2022, 101(1): 101549.

DOI：10.1016/j.psj.2021.101549

• Glycyrrhiza polysaccharides
• Newcastle disease
• immune response
• immune booster

Licorice is a medicinal and food plant widely used to treat diseases and produce food additives , because of its unique chemical constituents like polysaccharides , flavones , and saponins. Glycyrrhiza Pol-ysaccharides (GPS-1) are water-soluble neutral polysac-charides extracted from licorice. Currently , GPS-1 is administrated to chickens by gavage every d for 14 d to observe the impact of GPS-1 on the Newcastle disease vaccine. To determine the immunity of these chickens to blood serum levels of (HI) antibody, and immunoglobulins IgA and IgG were measured. Meanwhile, the expression levels of cytokines IL-2 , IL-4 , IL-17 , and IFN-g were measured to evaluate the degree of immune booster activity. The chickens' spleen and peripheral blood lymphocytes displayed a sig-nific a n t increase in the proportion of CD4+ and CD8+ T cells after booster treatments with GPS-1. The results indicated that GPS-1 had a significant , dose-dependent immune-boosting effect which could enha n c e NDV vac-cine immunity in chickens.

• 单位
  云南大学; y; 南京农业大学