Comparing the interaction of vanadyl-hypocrellin A complex and hypocrellin A with CT DNA

摘要

Interaction studies of the vanadyl-hypocrellin A (VO2+-HA) complex and hypocrellin A (HA) with CT DNA were investigated by UV-Vis spectroscopy, DNA melting, fluorescence spectra and zeta potential measurements. The binding constants and binding mechanisms of HA and VO2+-HA with CT DNA had also been studied by fluorescence quenching experiments. Both spectrophotometric and DNA melting studies indicated that VO2+-HA and HA could bind to CT DNA. Thermodynamic parameters together with zeta potential studies revealed that the binding force between HA or VO2+-HA with CT DNA was hydrophobic and electrostatic force, separately.

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