Copper-Catalyzed Oxidative 1,2-Alkylarylation of Styrenes with Unactivated C(sp3)-H Alkanes and Electron-Rich Aromatics via C(sp3)-H/C(sp2)-H Functionalization

作者：Jiang, Hui-Min; Sun, Qing; Jiang, Jin-Peng; Qin, Jing-Hao^*; Ouyang, Xuan-Hui^*; Song, Ren-Jie^*

来源：Advanced Synthesis and Catalysis, 2022, 364(16): 2772-2782.

DOI：10.1002/adsc.202200548

• alkenes
• copper-catalyzed
• alkanes
• C-H functionalization

We have disclosed an alkenes dicarbofunctionalization method to introduce alkyl and electron-rich aryl across the C=C bond of styrenes under copper catalyst and oxidative conditions, leading to construct C(sp(3))-C(sp(2))/C(sp(3))-C(sp(3)) bonds via dual C-H functionalization. This method realizes the synthesis of 1,1-diarylalkanes, which are very important skeleton in natural products and drug molecules, through the grafting of electron-rich aromatics, including indoles, pyrroles, trisubstituted aromatic.

• 单位
  南昌航空大学