Generation of an induced pluripotent stem cell line from an aortic dissection patient carrying MCTP2/c.2635T > G mutation

作者：Feng, Weiqi; Li, Chenxi; Li, Ying; Yang, Jue; Fan, Ruixin^*

来源：Stem Cell Research, 2023, 68: 103058.

DOI：10.1016/j.scr.2023.103058

Aortic dissection (AD) is a lethal cardiovascular disease that is related to a genetic mutation. This study showed the generation of induced pluripotent stem cell (iPSC) line (iPSC-ZPR-4-P10) from AD patients' peripheral blood mononuclear cells that carried a c.2635T > G mutation in MCTP2. The iPSC line demonstrated normal karyotype and expression of pluripotency markers, which could be an efficient tool to better investigate the mechanism of aortic dissection.

• 单位
  广东省心血管病研究所; 广东省人民医院