Utilization of Nonradiative Excited-State Dissipation for Promoted Phototheranostics Based on an AIE-Active Type I ROS Generator

作者：Wang, Yifei; Sun, Yudong; Ran, Jiabing; Yang, Huiran; Xiao, Shuzhang; Yang, Jing; Yang, Changying^*; Wang, Huimin^*; Liu, Yi^*

来源：ACS applied materials & interfaces, 2022, 14(1): 225-235.

DOI：10.1021/acsami.1c19008

• AIEgens
• nonradiative dissipation
• NS-STPA
• typ I ROS
• photodynamic therapy (PDT)
• intersystem crossing (ISC)

As for effective multimodal phototheranostic AlEgens, it is important to find strategies for manipulating photophysical dissipation to achieve optimized performance. Herein, a "all-in-one" phototheranostic AlEgen, (E)-3-(2-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-naphtho[1,2-d]thiazol-1-ium-1-yl)propane-1-sulfonate (NS-STPA) was constructed by a rigid coplanar grafting flexible rotor. NS-STPA nanoparticles (NPs) exhibited NIR fluorescent luminescence (FL) with phi(FL) 2.78%. Upon 660 nm irradiation, the high photothermal conversion efficiency (39.01%) and effective reactive oxygen species (ROS) generation (5.28 times to Ce6) indicated the nonradiative decays are valuable in phototherapy. High (OH)-O-center dot outputs showed NS-STPA NPs were outstanding type I ROS generators. The twisted D-A structure induced a large spin-orbit coupling (SOC), and insertion of thiophene decreased the S-1-T-1 energy gap (Delta E-ST). The nanoaggregate prolonged the triplet-state lifetime (tau(T)). These all facilitate the intersystem crossing (ISC) for NS-STPA NPs. The photoinduced electron transfer resulted in O-center dot(2)- and then (OH)-O-center dot generation. In vivo evaluation indicated the promising application of NS-STPA NPs in FL and photothermal dual imaging-guided synergistic photodynamic and photothermal therapies.

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