In situ decrypting plasmonic nanoparticle size-controlled phosphorylation of epidermal growth factor receptor in living cells

作者：Wang, Hongyan; Ding, Yan; Zhang, Yu; Shi, Xiaoqi; Liu, Honglin^*

来源：Chemical Communications, 2023, 59(62): 9493-9496.

DOI：10.1039/d3cc02154h

• NANOCONJUGATION

Recently, interaction between epidermal growth factor receptor (EGFR) and EGFR-targeted nanoprobes is a hot topic. Here, we use dark field microscope (DFM) observe different aggregations of EGFR-targeted nanoprobes in diverticulum. Different aggregation states are related to phosphorylation of EGFR. EGFR phosphorylation can be adjusted by gold nanoparticles (GNPs) size.

• 单位
  安徽医科大学; 1