Metal-Organic Cycle/Cage (MOC)-Based Supramolecular Photosensitizers: A Promising Strategy to Construct Robust Phototherapeutic Agents

Authors：Tuo, Wei; Li, Yuanyuan; Olenyuk, Bogdan; Sun, Yao; Sun, Yan; Stang, Peter J.^*

Source：Israel Journal of Chemistry, 2023, 63(7-8).

DOI：10.1002/ijch.202200121

• Metal-organic cycle
• cage (MOC)
• supramolecular photosensitizers
• phototherapeutic medicines

Metal-organic cycles/cages (MOCs) are discrete and well-defined molecular entities formed by coordination between metal centers and organic donors. To date, two-dimensional and three-dimensional suprastructures such as triangle, rhomboid, hexagon, and cube have been prepared. The tunable sizes and shapes endow MOCs with unique properties and promising applications in catalysis, sensors, and biomaterials. This review mainly covers achievements in the application of MOCs photosensitizers for the elimination of tumors and bacteria. Finally, it also discusses the future of MOCs for the design of novel type of photosensitizers and the possibility for novel therapeutic modalities.

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