Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the Tracerlab FXFN and Tracerlab MXFDG module for imaging the peripheral benzodiazepine receptor with PET

作者：Bourdier T^*; Pham T Q; Henderson D; Jackson T; Lam P; Izard M; Katsifis A

来源：Applied Radiation and Isotopes, 2012, 70(1): 176-183.

DOI：10.1016/j.apradiso.2011.07.014

• [18F]fluorination
• [18F]PBR102
• [18F]PBR111
• Tracerlab FXFN
• Tracerlab MXFDG

[18F]PBR111 and [18F]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [18F]PBR111 and [18F]PBR102 in the Tracerlab FXFN (30±2 radiochemical yield non-decay-corrected for both tracers) and Tracerlab MXFDG (25±2 radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was 99 and specific activity was 150GBq/μmol after less than 60min of preparation time.

• 单位
  Royal Prince Alfred Hospital