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摘要
Functional magnetic resonance imaging (fMRI) was used to observe the activation response of the hypothalamus under different intensity electrical stimulation, and to explore the role of thalamus in the pain regulation network. Ten subjects were selected as normal subjects, and 41 degrees C and 51 degrees C were performed on the dorsal side of the right forearm of all subjects, respectively. CCHS mission-mode functional magnetic resonance (fMRI) scans (41 degrees C. CCHS-fMRI group and 51 degrees C CHS-fMRI group) were pre-processed with fMRI using SPM8. A single sample t-test was used to compare 41 degrees C CCHS-fMRI group and 51 degrees C. The CCHS-fMRI group underwent intragroup analysis to observe the activation of brain regions under two different temperature CHS, and recorded the activation intensity of the activation region. A paired t-test was used to explore the difference in activation between the PD group and the control group, and brain regions with statistically significant differences were analyzed. The activation intensity of the activated brain region was recorded, and the cause of the difference was analyzed. At the end of the trial, the visual analog scale (CVAS) was used to score the pain experienced by the subject at the stimulation temperature, and then the subject was subjected to a sensory quantification test (QST), including the measurement of thermal sensation (WS) and thermal pain (HP). At the same time, under the same intensity electrical stimulation, the activation signal of the lateral thalamus was stronger than that of the lateral thalamus, showing a contralateral advantage, while the bilateral thalamus lacked this manifestation. The thalamus should be an important component of the pain-regulating network. This region exhibits a segregation-activated phenomenon, and each region has its own unique stimulatory response characteristics, which helps to understand the role of the thalamus in the treatment of pain information.
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单位1; 南方医科大学
