Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways

作者：Gao Si; Chen Tianfeng^*; Choi Mei Yuk; Liang Yuanwei; Xue Junyi; Wong Yum Shing

来源：Cancer Letters, 2013, 333(1): 36-46.

DOI：10.1016/j.canlet.2012.12.029

• Cisplatin
• Apoptosis
• AKT
• ERK
• Cyanidin

Cyanidin is an anthocyanin widely distributed in food diet with novel antioxidant activity. Herein, we investigated the protective effects of cyanidin on HK-2 proximal tubular cells against cisplatin-induced apoptosis and elucidated the underlying mechanisms. The results showed that cisplatin-induced apoptosis in HK-2 cells was significantly attenuated by cyanidin. The cleavage of caspases and PARP, activation of p53 and mitochondrial-mediated apoptosis pathways induced by cisplatin were effectively blocked by cyanidin. Moreover, cyanidin significantly suppressed the overproduction of ROS, and activation of ERK and AKT pathways triggered by cisplatin. Our results indicate that cyanidin exhibits therapeutic potential in prevention of cisplatin-induced nephrotoxicity.

• 单位
  济南大学; 香港大学; 暨南大学